Antipsychotic Drugs and Cerebrovascular Events in Elderly Patients with Dementia: A Systematic Review

Sara      Mazzucco; Andrea      Cipriani; Corrado      Barbui; Salvatore      Monaco

Abstract

Recently, Canadian, US and European health regulatory agencies issued warnings about an increased risk of stroke and death in elderly patients with dementia receiving atypical antipsychotics. Assessing both randomised and nonrandomised evidence, this systematic review found conflicting findings, particularly for risperidone. More research is needed to better inform clinical practice.

Keywords: Neuroleptics, typical antipsychotics, atypical antipsychotics, dopamine, dementia, cerebrovascular events

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