Abstract
Tumor invasion and cancer metastasis are interrelated processes involving cell growth, cell adhesion, cell migration and proteolytic degradation of tissue barriers, which are mediated by aberrant intracellular signaling in cancer cells. Natural (green tea polyphenols, soy isoflavones) or dietary compounds (mushroom G. lucidum) markedly decreased AP-1 and NF-κB signaling and suppressed invasiveness of cancer cells. This review will summarize alternative approaches for the inhibition of invasive behavior of cancer cells by dietary compounds, which can be considered in adjuvant or combination therapy for the prevention and treatment of cancer metastasis.
Keywords: Cancer invasion, metastasis, green tea, isoflavones, triterpenes, signaling
Mini-Reviews in Medicinal Chemistry
Title: Suppression of Cancer Invasiveness by Dietary Compounds
Volume: 8 Issue: 7
Author(s): Daniel Sliva
Affiliation:
Keywords: Cancer invasion, metastasis, green tea, isoflavones, triterpenes, signaling
Abstract: Tumor invasion and cancer metastasis are interrelated processes involving cell growth, cell adhesion, cell migration and proteolytic degradation of tissue barriers, which are mediated by aberrant intracellular signaling in cancer cells. Natural (green tea polyphenols, soy isoflavones) or dietary compounds (mushroom G. lucidum) markedly decreased AP-1 and NF-κB signaling and suppressed invasiveness of cancer cells. This review will summarize alternative approaches for the inhibition of invasive behavior of cancer cells by dietary compounds, which can be considered in adjuvant or combination therapy for the prevention and treatment of cancer metastasis.
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Cite this article as:
Sliva Daniel, Suppression of Cancer Invasiveness by Dietary Compounds, Mini-Reviews in Medicinal Chemistry 2008; 8 (7) . https://dx.doi.org/10.2174/138955708784567412
DOI https://dx.doi.org/10.2174/138955708784567412 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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