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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Endothelial Lipase: A Key Player in HDL Metabolism Modulates Inflammation and Atherosclerotic Risk

Author(s): Pascual DeSantis, Trey Coleman, Stephan Schiekofer, Peter P. Nawroth, Paul Schlimmer and Jochen G. Schneider

Volume 8, Issue 6, 2008

Page: [619 - 627] Pages: 9

DOI: 10.2174/138955708784534427

Price: $65


Endothelial Lipase (EL) is a newly identified member of the triacylglycerol lipase family. Recent studies suggested that EL may be an important determinant of HDL-metabolism and inflammation acting at the level of the vessel wall. The aim of this review is to summarize important facts derived from experimental approaches and from epidemiologic human studies to provide a comprehensive view on the role of EL in inflammation and atherogenesis as well as target for potential pharmaceutical interventions.

Keywords: HDL metabolism, atherosclerosis, inflammation

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