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Current Bioinformatics


ISSN (Print): 1574-8936
ISSN (Online): 2212-392X

An Integrated Rule-Set for Protein Localization in Plasmodium falciparum

Author(s): Aditya Rao, Sri Jyothsna Yeleswarapu, Rajgopal Srinivasan and Gopalakrishnan Bulusu

Volume 3 , Issue 2 , 2008

Page: [66 - 73] Pages: 8

DOI: 10.2174/157489308784340685

Price: $65


Proteins localize to many intracellular and extracellular organelles in the malarial parasite Plasmodium falciparum. Although organellar localization in the parasite has been studied in detail, there is a need for a comprehensive ruleset that captures the different paths and mechanisms used by proteins for localization. This review is an attempt to build such a rule-set through a combination of rules gleaned from literature reports. A prototype localization prediction tool has also been implemented by incorporating certain sequence/composition rules from the rule-set.

Keywords: Plasmodium falciparum, protein localization, integrated rule-set, Targetpf

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