An Example of Total Synthesis of Flavones by Heck-Sonogashira-Cassar Reaction

Title: An Example of Total Synthesis of Flavones by Heck-Sonogashira-Cassar Reaction

Volume: 5 Issue: 4

Author(s): Armandodoriano Bianco, Claudia Cavarischia, Marcella Guiso and Teresa Matini

Affiliation:

Keywords: Heck-Sonogashira-Cassar reactions, aryl-alkynyl ketones, propargyl alcohols, flavones, palladium

Abstract: The use of aryl vinyl ketones in the Heck reaction for the synthesis of flavonoids was previously described. Herein we present our preliminary study on the reactivity of aroyl alkynes or propargyl alcohols in the Heck-Sonogashira- Cassar coupling reactions to obtain alkynyl precursors of flavones. This procedure envisaged a general protocol for the synthesis of variously substituted flavones.

Cite this article as:

Bianco Armandodoriano, Cavarischia Claudia, Guiso Marcella and Matini Teresa, An Example of Total Synthesis of Flavones by Heck-Sonogashira-Cassar Reaction, Letters in Organic Chemistry 2008; 5 (4) . https://dx.doi.org/10.2174/157017808784049542