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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Synthesis of NH-Aziridines from Vicinal Amino Alcohols Via the Wenker Reaction: Scope and Limitation

Author(s): Min Zhu, Libo Hu, Ning Chen, Da-Ming Du and Jiaxi Xu

Volume 5 , Issue 3 , 2008

Page: [212 - 217] Pages: 6

DOI: 10.2174/157017808783955844

Price: $65


The Wenker reaction is an efficient and practical method for the synthesis of NH-aziridines from vicinal amino alcohols. However, some limitation in the application has been reported. The scope and limitation of the Wenker reaction were investigated with a series of structurally diverse and representative vicinal amino alcohols.

Keywords: Aziridine, amino alcohol, cyclization, heterocyclic compound, Wenker reaction, synthesis

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