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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Regioselective Synthesis of Oxepin and Oxocin Annulated Quinoline Heterocycles by Ring-Closing Metathesis

Author(s): Krishna C. Majumdar, Pradip Debnath and Abu Taher

Volume 5, Issue 3, 2008

Page: [169 - 173] Pages: 5

DOI: 10.2174/157017808783955871

Price: $65


Regioselective synthesis of oxepin and oxocin annulated quinoline heterocycles by the combination of Claisen rearrangement and ring-closing metathesis reaction is described. The ring-closing metathesis (RCM) and ring-closing enyne metathesis (RCEM) proceeded smoothly in the presence of Grubbs catalyst A or B in toluene under nitrogen atmosphere without deactivation of the basic quinoline nitrogen.

Keywords: Ring-closing metathesis, oxepine, oxocine, quinoline derivatives, Grubb's catalyst

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