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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Regioselective Alkylation of Pyrrole with 2-Benzylidenemalononitriles Catalyzed by Cu(OTf)2

Author(s): Dilek I. Tasgin, Baris Temelli, Arife Yazici, Sertan Aytac and Canan Unaleroglu

Volume 5 , Issue 3 , 2008

Page: [165 - 168] Pages: 4

DOI: 10.2174/157017808783955763

Price: $65


Copper triflate was used as catalyst for the addition of pyrrole to 2-benzylidenemalononitrile and its substituted derivatives. 2-Alkylated pyrrole derivatives were regioselectively obtained in mild reaction conditions. The addition reactions were found to be highly dependent on the substituents of the phenyl group.

Keywords: Metal triflates, pyrrole, alkylated pyrrole, Michael addition, direct alkylation, benzylidenemalononitrile

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