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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Inhibition of Orotidine 5-Monophosphate Decarboxylase and Its Therapeutic Potential

Author(s): L. P. Kotra, M. E. Meza-Avina, L. Wei, M. G. Buhendwa, E. Poduch, A. M. Bello and E. F. Pai

Volume 8, Issue 3, 2008

Page: [239 - 247] Pages: 9

DOI: 10.2174/138955708783744065

Price: $65


Orotidine 5-monophosphate decarboxylase (ODCase) is among the most proficient enzymes, and catalyzes the decarboxylation of OMP to UMP. An overview of ODCase and various proposals for its catalytic mechanism of decarboxylation are briefly presented here. A number of inhibitors of ODCase and new developments in the X-ray structures of ODCases from different species are discussed in the context of their therapeutic potential against cancer and infectious diseases. Latest discoveries in the inhibition of ODCase, for example using the novel C6 substitutions on the uridine, open new doors for drug discovery targeting parasitic diseases such as malaria.

Keywords: Orotidine 5'-monophosphate decarboxylase, de novo nucleotide synthesis, pyrimidine nucleotides, drug design

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