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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Malaria Combination Therapies: Advantages and Shortcomings

Author(s): A. Martinelli, R. Moreira and P. V.L. Cravo

Volume 8, Issue 3, 2008

Page: [201 - 212] Pages: 12

DOI: 10.2174/138955708783744092

Price: $65


Drug combination therapies have been devised to delay the development and spread of resistant malaria parasites. However, poor design often leads to ineffective combinations. Here, the properties of various drug combinations are reviewed in relationship to drug resistance and their pharmacokinetic compatibility.

Keywords: Malaria, drug resistance, drug combination therapy, artemisinin, quinolines, antifolates

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