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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Glucocorticoid Measurements in Health and Disease - Metabolic Implications and the Potential of 24-h Urine Analyses

Author(s): Thomas Remer, Christiane Maser-Gluth and Stefan A. Wudy

Volume 8, Issue 2, 2008

Page: [153 - 170] Pages: 18

DOI: 10.2174/138955708783498096

Price: $65


For examination of glucocorticoid metabolism and identification of hyper and hypocortisolism, various measurements and diagnostic tools are available. After a brief overview of the physiology of glucocorticoid secretion and glucocorticoid actions, the currently used measurements for blood, saliva, and urine samples and the corresponding physiological and metabolic implications are critically reviewed. A special emphasis is placed on the potential of 24-h urine analyses to assess not only glucocorticoid secretion, but also functional glucocorticoid activity.

Keywords: Glucocorticoid measurements, cortisol, cortisone, urinary free steroids, functional glucocorticoid activity, 11betahydroxysteroid dehydrogenase, 5alpha-reductase, 24-h urine collection, children

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