Crystallization and Preliminary X-Ray Analysis of Anti-Obesity Peptide Hormone Oxyntomodulin

Title: Crystallization and Preliminary X-Ray Analysis of Anti-Obesity Peptide Hormone Oxyntomodulin

Volume: 15 Issue: 2

Author(s): Faming Zhang, Pengyun Li, Tanya Rogers, David Smiley, Richard D. DiMarchi and Richard D DiMarchi

Affiliation:

Keywords: Oxyntomodulin, glucagon, GLP-1, diabetes, obesity, crystallization, synthesis

Abstract: Oxyntomodulin is a proglucagon-derived gut hormone that reduces food intake and body weight, thus represents a potential therapy for obesity. We synthesized and crystallized oxyntomodulin. The crystal diffracts x-ray to 2.4 Å resolution and belongs to space group P213 with unit-cell parameters a=b=c= 48.44 Å , α=β=γ=90°. Preliminary analysis indicates a trimer packing in one asymmetric unit.

Cite this article as:

Zhang Faming, Li Pengyun, Rogers Tanya, Smiley David, DiMarchi D. Richard and D DiMarchi Richard, Crystallization and Preliminary X-Ray Analysis of Anti-Obesity Peptide Hormone Oxyntomodulin, Protein & Peptide Letters 2008; 15 (2) . https://dx.doi.org/10.2174/092986608783489643