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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

S-adenosylmethionine Inhibits Ubiquitin-Proteasome System In Vitro and on Rat Vascular Smooth Muscle Cells

Author(s): Fabrizio D'Anselmi, Alessandra Cucina, Giuseppe Cavallaro, Mariano Bizzarri, Rosaria Adele Cavallaro, Andrea Fuso, Antonino Cavallaro and Sigfrido Scarpa

Volume 15, Issue 1, 2008

Page: [58 - 62] Pages: 5

DOI: 10.2174/092986608783330396

Price: $65


S-adenosylmethionine is a metabolite regulating many biological processes; S-adenosylmethionine effect on ubiquitin-proteasome system (UPS) has not been studied yet. We investigated S-adenosylmethionine effects on UPS activity both in vitro, by inhibitor screening assay, and in rat vascular smooth muscle cells, by Western Blot of proteasomal targets. We found that S-adenosylmethionine inhibited UPS activity.

Keywords: Ubiquitin-proteasome system, 20S proteasome, S-adenosylmethionine, vascular smooth muscle cells, atherosclerosis, Sulfur-containing aminoacids cycle

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