Detection of a γ-Carboxy-Glutamate as Novel Post-Translational Modification of Human Transthyretin

Title: Detection of a γ-Carboxy-Glutamate as Novel Post-Translational Modification of Human Transthyretin

Volume: 15 Issue: 1

Author(s): Thomas Franz, Sabrina Ruggeberg, Peter Horn, Xinping Li and Peter Vajkoczy

Affiliation:

• European Molecular Biology Laboratory, Proteomic Core Facility, Meyerhofstr. 1, 69117 Heidelberg, Germany.,Germany

Keywords: γ-Carboxy-glutamate, cerebrospinal fluid, moyamoya disease, post-translational modification, human transthyretin, two-dimensional gel electrophoresis

Abstract: During analysis of the proteome in the cerebrospinal fluid (CSF) of the Caucasian form of moyamoya disease (MMD), a novel post-translational modification of human transthyretin was observed. Two-dimensional electrophoresis and subsequent peptide sequencing with ESI-MS/MS were performed to discover the γ-carboxylation of the Glu-42 (Gla- 42).

Cite this article as:

Franz Thomas, Ruggeberg Sabrina, Horn Peter, Li Xinping and Vajkoczy Peter, Detection of a γ-Carboxy-Glutamate as Novel Post-Translational Modification of Human Transthyretin, Protein & Peptide Letters 2008; 15(1) . https://dx.doi.org/10.2174/092986608783330297