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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Detection of a γ-Carboxy-Glutamate as Novel Post-Translational Modification of Human Transthyretin

Author(s): Thomas Franz, Sabrina Ruggeberg, Peter Horn, Xinping Li and Peter Vajkoczy

Volume 15, Issue 1, 2008

Page: [43 - 46] Pages: 4

DOI: 10.2174/092986608783330297

Price: $65


During analysis of the proteome in the cerebrospinal fluid (CSF) of the Caucasian form of moyamoya disease (MMD), a novel post-translational modification of human transthyretin was observed. Two-dimensional electrophoresis and subsequent peptide sequencing with ESI-MS/MS were performed to discover the γ-carboxylation of the Glu-42 (Gla- 42).

Keywords: γ-Carboxy-glutamate, cerebrospinal fluid, moyamoya disease, post-translational modification, human transthyretin, two-dimensional gel electrophoresis

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