Abstract
Patient response to asthma therapy is consistently observed to be heterogeneous. Pharmacogenomics is the study of inherited differences in interindividual drug disposition and effects, with the goal of selecting the optimal drug therapy and dosage for each patient. This review will cover selected examples of gene polymorphisms that influence the outcome of asthma therapy, and whole-genome expression studies using microarray technology that have shown tremendous potential for benefiting asthma pharmacogenomics. The utility of the mouse as an experimental system for pharmacogenomic discovery will also be discussed in the context of asthma therapy.
Keywords: Asthma, pharmacogenomics
Current Pharmaceutical Design
Title: Pharmacogenomics of Asthma
Volume: 12 Issue: 25
Author(s): Andreas Pahl, Ewald Benediktus and Ligia Chialda
Affiliation:
Keywords: Asthma, pharmacogenomics
Abstract: Patient response to asthma therapy is consistently observed to be heterogeneous. Pharmacogenomics is the study of inherited differences in interindividual drug disposition and effects, with the goal of selecting the optimal drug therapy and dosage for each patient. This review will cover selected examples of gene polymorphisms that influence the outcome of asthma therapy, and whole-genome expression studies using microarray technology that have shown tremendous potential for benefiting asthma pharmacogenomics. The utility of the mouse as an experimental system for pharmacogenomic discovery will also be discussed in the context of asthma therapy.
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Cite this article as:
Pahl Andreas, Benediktus Ewald and Chialda Ligia, Pharmacogenomics of Asthma, Current Pharmaceutical Design 2006; 12 (25) . https://dx.doi.org/10.2174/138161206778194105
DOI https://dx.doi.org/10.2174/138161206778194105 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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