Synthesis and Transformation of Thiazolomorphinanedienes

Title: Synthesis and Transformation of Thiazolomorphinanedienes

Volume: 4 Issue: 8

Author(s): Miklos Toth, Zsuzsanna Gyulai, Sandor Berenyi and Attila Sipos

Affiliation:

Keywords: Hantzsch-type thiazole synthesis, morphinanediene, O-demethylation, introduction of 14-hydroxyl-motif

Abstract: We here present a simple and efficient method for the preparation of 2-substituted-thiazolomorphinanedienes 3-5. A protocol is also presented for yielding 3-demethoxy-14β-hydroxy derivatives of the thiazolomorphianedienes. The amino-, methyl- and phenyl-substituents connected in these compounds in a less rigid way to the “spacer” which offers the opportunity to test the effect of this sterically more flexible structure on the activity to opioid receptor subtypes.

Cite this article as:

Toth Miklos, Gyulai Zsuzsanna, Berenyi Sandor and Sipos Attila, Synthesis and Transformation of Thiazolomorphinanedienes, Letters in Organic Chemistry 2007; 4 (8) . https://dx.doi.org/10.2174/157017807782795538