Design and Synthesis of a (N-Alkylaminoalkyl-Substituted)Arylalkenylamide Drug Discovery Library

Title: Design and Synthesis of a (N-Alkylaminoalkyl-Substituted)Arylalkenylamide Drug Discovery Library

Volume: 4 Issue: 8

Author(s): M. Urbano, S. Collina, D. Rossi, A. Carnevale Baraglia, S. Alcaro, A. Artese and O. Azzolina

Affiliation:

• Dipartimento di Chimica Farmaceutica, Universita di Pavia,Viale Taramelli 12, 27100, Pavia, Italy.,Italy

Keywords: Discovery library, Sigma ligands, Arylalkenylamidic scaffold, PASPS, MAOS, Molecular modeling

Abstract: To discover new potential sigma ligands, a library of 64 members based on a carbamidic scaffold was designed and a synthetic protocol, based on PASPS and MAOS techniques, was developed and optimized. Applying the developed protocol the library compounds were obtained in high purity, suitable for biological screening.

Cite this article as:

Urbano M., Collina S., Rossi D., Baraglia Carnevale A., Alcaro S., Artese A. and Azzolina O., Design and Synthesis of a (N-Alkylaminoalkyl-Substituted)Arylalkenylamide Drug Discovery Library, Letters in Drug Design & Discovery 2007; 4(8) . https://dx.doi.org/10.2174/157018007782794581