Abstract
To discover new potential sigma ligands, a library of 64 members based on a carbamidic scaffold was designed and a synthetic protocol, based on PASPS and MAOS techniques, was developed and optimized. Applying the developed protocol the library compounds were obtained in high purity, suitable for biological screening.
Keywords: Discovery library, Sigma ligands, Arylalkenylamidic scaffold, PASPS, MAOS, Molecular modeling
Letters in Drug Design & Discovery
Title: Design and Synthesis of a (N-Alkylaminoalkyl-Substituted)Arylalkenylamide Drug Discovery Library
Volume: 4 Issue: 8
Author(s): M. Urbano, S. Collina, D. Rossi, A. Carnevale Baraglia, S. Alcaro, A. Artese and O. Azzolina
Affiliation:
- Dipartimento di Chimica Farmaceutica, Universita di Pavia,Viale Taramelli 12, 27100, Pavia, Italy.,Italy
Keywords: Discovery library, Sigma ligands, Arylalkenylamidic scaffold, PASPS, MAOS, Molecular modeling
Abstract: To discover new potential sigma ligands, a library of 64 members based on a carbamidic scaffold was designed and a synthetic protocol, based on PASPS and MAOS techniques, was developed and optimized. Applying the developed protocol the library compounds were obtained in high purity, suitable for biological screening.
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Cite this article as:
Urbano M., Collina S., Rossi D., Baraglia Carnevale A., Alcaro S., Artese A. and Azzolina O., Design and Synthesis of a (N-Alkylaminoalkyl-Substituted)Arylalkenylamide Drug Discovery Library, Letters in Drug Design & Discovery 2007; 4(8) . https://dx.doi.org/10.2174/157018007782794581
DOI https://dx.doi.org/10.2174/157018007782794581 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |

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