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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Design, Synthesis and Biological Activity of A-C8/C-C2-Linked 6-Chloropurine-Pyrrolobenzodiazepine Hybrids as Anticancer Agents

Author(s): Ahmed Kamal, N. Shankaraiah, K. Laxma Reddy, V. Devaiah, Aarti Juvekar and Subrata Sen

Volume 4 , Issue 8 , 2007

Page: [596 - 604] Pages: 9

DOI: 10.2174/157018007782794482

Price: $65


New A-C8 and C-C2-linked 6-chloropurine-pyrrolo[2,1-c][1,4]benzodiazepine hybrids have been prepared and evaluated for their anticancer potential. The molecular modeling studies might be explained in terms of effect of the molecule on binding in the minor groove of DNA and also comparison to both A-C8/C-C2-position of the PBD. These PBD conjugates have shown DNA-binding ability and promising anticancer activity.

Keywords: Pyrrolo[2,1-c][1,4]benzodiazepines, 6-chloropurine nucleosides, DNA-binding affinity, Anticancer activity

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