An Efficient Synthesis of Quinoline Derivatives: Bio-Active Studies

Title: An Efficient Synthesis of Quinoline Derivatives: Bio-Active Studies

Volume: 4 Issue: 8

Author(s): Ahmed Kamal, K. Srinivasa Reddy, M. Naseer A. Khan, Rajesh V.C.R.N.C. Shetty, S. Kaleem Ahmed, K. Pranay Kumar and U. S.N. Murty

Affiliation:

Keywords: Quinolines, Benzothiadiazines, Al(OTf)3, Friedlander synthesis, TMSCl-NaI, One-pot method, Triazolobenzothiadiazine, Antibacterial activity

Abstract: A new method for the synthesis of quinolines has been developed by employing various novel catalysts such as Al(OTf)3, Gd(OTf)3, and TMSCl-NaI. Later, these compounds were condensed with 3-hydrazino benzothiadiazines to obtain quinoline derived [1,2,4]triazolo[1,5-b][1,2,4] benzothiadiazines. Further, these new molecules have been evaluated for their antibacterial activity and some of them have exhibited significant antibacterial activity in comparison to sulfadiazine.

Cite this article as:

Kamal Ahmed, Reddy Srinivasa K., Khan A. M. Naseer, Shetty V.C.R.N.C. Rajesh, Ahmed Kaleem S., Kumar Pranay K. and Murty S.N. U., An Efficient Synthesis of Quinoline Derivatives: Bio-Active Studies, Letters in Drug Design & Discovery 2007; 4 (8) . https://dx.doi.org/10.2174/157018007782794536