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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis and Biological Evaluation of a New Series of Benzothiazole-Benzothiadiazine Conjugates as Antibacterial Agents

Author(s): Ahmed Kamal, S. Kaleem Ahmed, K. Srinivasa Reddy, M. Naseer A. Khan, Rajesh V.C.R.N.C. Shetty, B. Siddhardha, U. S.N. Murty, Arnab China and V. Nagaraja

Volume 4 , Issue 8 , 2007

Page: [550 - 556] Pages: 7

DOI: 10.2174/157018007782794563

Price: $65


A new series of benzothiazolo-benzothiadiazine hybrids (9a-g) has been synthesized and evaluated for their antibacterial activity against clinical isolates of Gram-positive and Gram-negative bacteria. Some of these hybrids in this series exhibited antibacterial activity comparable to ampicillin. In addition, some of the compounds showed DNA gyrase inhibitory activity at a moderate level compared to ciprofloxacin.

Keywords: Benzothiadiazines, Benzothiazoles, Antibacterial activity, DNA gyrase inhibition

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