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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Inhibition of Aromatase (AR) by Benzyl Azole-Based Compounds

Author(s): Shaheen Adat, Caroline P. Owen and Sabbir Ahmed

Volume 4 , Issue 8 , 2007

Page: [545 - 549] Pages: 5

DOI: 10.2174/157018007782794554

Price: $65


We report the results of the evaluation of a series of benzyl imidazole-based compounds against the enzyme aromatase (AR). The results show that the synthesised compounds were potent inhibitors of AR in comparison to the standard compound aminoglutethimide (AG).

Keywords: Enzyme, Inhibition, Azole, Estrogen synthetase, Aromatase

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