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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Spectroscopic and Functional Characterization of Human β-Synuclein

Author(s): Juhyung Lee, Heejin Hwang and T. Doohun Kim

Volume 14, Issue 10, 2007

Page: [1021 - 1026] Pages: 6

DOI: 10.2174/092986607782541132

Price: $65

Abstract

To elucidate potential biological roles of human β-synuclein, we studied its conformational changes under various conditions. The structural and functional properties of β-synuclein were characterized using biochemical and biophysical methods including: a functional assay, mass spectrometry, size exclusion chromatography, circular dichroism (CD), and fluorescence spectroscopy. The results showed β-synuclein has a high proportion of random coil in solution.

Keywords: β-Synuclein, circular dichroism, fluorescence, conformational change


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