Abstract
Stroke is one of the leading causes of mortality, and several risk factors have been identified that may be modified to ameliorate this risk. Recently, obstructive sleep apnea (OSA) has been implicated as a possible additional risk factor for stroke. OSA is a common disorder characterized by repeated upper airway collapse during sleep leading to multiple physiologic abnormalities. Several recent studies suggest that OSA is an independent risk factor for stroke. This independent association is likely due to derangement of normal sleep physiology and the attendant consequences to autonomic, vascular endothelial, and thrombotic/fibrinolytic dysfunction leading to the development of atherosclerosis. Additionally, OSAs contribution to the development of known risk factors for stroke such as hypertension and atrial fibrillation may also predispose a patient to develop cerebrovascular disease. Patients presenting with stroke who are also diagnosed with OSA have a worse prognosis than those without OSA. Therapy with continuous positive airway pressure (CPAP), the treatment of choice for most patients with OSA, appears to be beneficial, but achieving compliance in patients post-stroke is difficult.
Keywords: non-rapid eye movement phase, cerebral blood flow, patent foramen ovale, CPAP therapy, Nitric oxide
Current Respiratory Medicine Reviews
Title: Obstructive Sleep Apnea and Stroke
Volume: 3 Issue: 4
Author(s): Philip M. Alapat
Affiliation:
Keywords: non-rapid eye movement phase, cerebral blood flow, patent foramen ovale, CPAP therapy, Nitric oxide
Abstract: Stroke is one of the leading causes of mortality, and several risk factors have been identified that may be modified to ameliorate this risk. Recently, obstructive sleep apnea (OSA) has been implicated as a possible additional risk factor for stroke. OSA is a common disorder characterized by repeated upper airway collapse during sleep leading to multiple physiologic abnormalities. Several recent studies suggest that OSA is an independent risk factor for stroke. This independent association is likely due to derangement of normal sleep physiology and the attendant consequences to autonomic, vascular endothelial, and thrombotic/fibrinolytic dysfunction leading to the development of atherosclerosis. Additionally, OSAs contribution to the development of known risk factors for stroke such as hypertension and atrial fibrillation may also predispose a patient to develop cerebrovascular disease. Patients presenting with stroke who are also diagnosed with OSA have a worse prognosis than those without OSA. Therapy with continuous positive airway pressure (CPAP), the treatment of choice for most patients with OSA, appears to be beneficial, but achieving compliance in patients post-stroke is difficult.
Export Options
About this article
Cite this article as:
Alapat M. Philip, Obstructive Sleep Apnea and Stroke, Current Respiratory Medicine Reviews 2007; 3 (4) . https://dx.doi.org/10.2174/157339807782359913
DOI https://dx.doi.org/10.2174/157339807782359913 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
Call for Papers in Thematic Issues
Exposure to PM2.5 components is associated with respiratory diseases
Through continuous research on the relationship between risk factors and health, it has been found that air pollution, especially atmospheric particulate matter pollution, has become one of the main sources of global disease burden. From 1990 to 2022, the concentration of atmospheric particulate matter pollution has increased by more than ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
20-Hydroxyeicosatetraenoic Acid is a Potential Therapeutic Target in Cardiovascular Diseases
Current Drug Metabolism Mitochondrial Dysfunction and Targeted Drugs: A Focus on Diabetes
Current Pharmaceutical Design Subject Index To Volume 1
Recent Patents on Cardiovascular Drug Discovery Dietary Factors and Hyperuricaemia
Current Pharmaceutical Design Endothelial Cell Regulation of Cardiac Metabolism Following Diabetes
Cardiovascular & Hematological Disorders-Drug Targets Diabetic Retinopathy: Current and New Treatment Options
Current Diabetes Reviews COVID-19 Treatment Success After Repeat Courses of Azithromycin: A Report of Three Cases
Infectious Disorders - Drug Targets The Impact of Asymmetric Dimethylarginine (ADAMA), the Endogenous Nitric Oxide (NO) Synthase Inhibitor, to the Pathogenesis of Gastric Mucosal Damage
Current Pharmaceutical Design Polyphenols: Inflammation
Current Pharmaceutical Design Biogenic Amines (BAs) in Meat Products, Regulatory Policies, and Detection Methods
Current Nutrition & Food Science Early Life Programming of Obesity: The Impact of the Perinatal Environment on the Development of Obesity and Metabolic Dysfunction in the Offspring.
Current Diabetes Reviews Cord Blood as Diagnostic Window for Preeclampsia
Recent Patents on Biomarkers Perinatal Management of Fetal Tumors
Current Pediatric Reviews The Protective Effects and Mechanism of Resveratrol-loaded Nanoparticles on HK-2 Cells Suffering from Hypoxia-reoxygenayion
Current Signal Transduction Therapy Role of NLRP-3 Inflammasome in Hypertension: A Potential Therapeutic Target
Current Pharmaceutical Biotechnology Long Chain n-3 Polyunsaturated Fatty Acids in the Prevention of Allergic and Cardiovascular Disease
Current Pharmaceutical Design Structural and Molecular Tear Film Changes in Glaucoma
Current Medicinal Chemistry Novel Coronavirus Disease 2019 (COVID-19) Current Update: Perspective on Epidemiology, Diagnosis, Drug Targets and Vaccines
Coronaviruses Statins Influence Long Term Restenosis and Cardiovascular Events Following Carotid Endarterectomy
Current Vascular Pharmacology Remifentanil with or without Propofol as Anesthesia Agents for Trans- Vaginal Ultrasonography Oocyte Retrieval (TUGOR) on Pregnancy and Anesthesia Outcomes: A Randomized Controlled Trial
Current Reviews in Clinical and Experimental Pharmacology