Antibody Directed Enzyme Prodrug Therapy (ADEPT) and Related Approaches for Anticancer Therapy

M.      Jung

Abstract

In antibody directed enzyme prodrug therapy (ADEPT) an antibody bound enzyme is targeted to tumor cells. This allows for selective activation of a nontoxic prodrug to a cytotoxic agent at the tumor site for cancer therapy. Site-selective prodrug activation results in reduced side effects in remote tissue. This article reviews ADEPT with emphasis on the chemical viewpoint and recent developments.

Keywords: Antibody Directed Enzyme Prodrug Therapy, ADEPT, Anticancer Therapy, Alkaline Phosphatase, Amino Peptidases, Aryl Sulfatase, Carboxylesterase, Carboxypeptidase A, Carboxypeptidase G2 (CpG2), Cytosine Deaminase