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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Assessing the Potential Toxicity of New Pharmaceuticals

Author(s): Dale E. Johnson and Grushenka H.I. Wolfgang

Volume 1, Issue 4, 2001

Page: [233 - 245] Pages: 13

DOI: 10.2174/1568026013395128

Price: $65

Abstract

Optimizing chemical structures to create potentially safe drugs during discovery and early development relies on a combination of predictive algorithms, screening, formal toxicology studies, and early clinical trials. Early in the process three critical questions emerge that must be answered by a detailed profiling approach. These questions are: 1) is there a correlation between the chemical structure and potential toxicity that can be used to optimize structures of lead compounds, 2) can specific markers of potential toxicity can be identified early and used as mechanistic decision-making screens, and 3) will exposures (plasma levels) in animal studies correlate with exposures encountered in the clinic thereby providing coverage for safety? Depending on the therapeutic class of compounds being considered and the level of knowledge available, feedback loops of information can be established to guide the development process.

Keywords: Toxicity, Pharmaceuticals, Toxicants

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