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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Peripheral and Dual Binding Site Acetylcholinesterase Inhibitors: Implications in treatment of Alzheimers Disease

Author(s): Ana Castro and Ana Martinez

Volume 1, Issue 3, 2001

Page: [267 - 272] Pages: 6

DOI: 10.2174/1389557013406864

Price: $65


Recently advances in understanding the molecular basis of Alzheimers disease have led to the consideration of the relationship between cholinergic inhibitors and amyloid deposition as a new hypothesis for the future rational design of effective anti-Alzheimer drugs. In the present review, the non-cholinergic functions of acetylcholinesterase (AChE) and the therapeutic potential of peripheral and dual binding site AChE inhibitors in delaying the neurodegenerative process will be discussed.

Keywords: Acetylcholinesterase Inhibitors, Alzheimers Disease, Anti-Alzheimer drugs

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