Abstract
Temporin A, 18 analogs, and a cecropin A-temporin A hybrid peptide were tested with antibiotic sensitive and resistant bacteria, fungi, human erythrocytes, and in clotting assays.Several peptides were active in these assays, and some analogs (D-TA, W1-TA, and Con-L4,G10) may be useful lead compounds for further antibiotics development.The activity of temporin A was found to be dependent upon several of its structural features, including amino acid composition and sequence, chirality, helicity, and positive charge.
Keywords: temporin a, cecropin a, vescp-m, ranatuerin 6, antibiotic peptides, antibiotic resistant bacteria, antifungal, human erythrocyte lysis, hemolysis
Protein & Peptide Letters
Title: Antibiotic Properties of Novel Synthetic Temporin A Analogs and a Cecropin A-Temporin A Hybrid Peptide
Volume: 9 Issue: 6
Author(s): David Wade, Jan-Ingmar Flock, Charlotta Edlund, Ingegerd Lofving-Arvholm, Matti Sallberg, Tomas Bergman, Angela Silveira, Cecille Unson, Louise Rollins-Smith, Jerzy Silberring, Malcom Richardson, Pentti Kuusela and Hilkka Lankinen
Affiliation:
Keywords: temporin a, cecropin a, vescp-m, ranatuerin 6, antibiotic peptides, antibiotic resistant bacteria, antifungal, human erythrocyte lysis, hemolysis
Abstract: Temporin A, 18 analogs, and a cecropin A-temporin A hybrid peptide were tested with antibiotic sensitive and resistant bacteria, fungi, human erythrocytes, and in clotting assays.Several peptides were active in these assays, and some analogs (D-TA, W1-TA, and Con-L4,G10) may be useful lead compounds for further antibiotics development.The activity of temporin A was found to be dependent upon several of its structural features, including amino acid composition and sequence, chirality, helicity, and positive charge.
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Wade David, Flock Jan-Ingmar, Edlund Charlotta, Lofving-Arvholm Ingegerd, Sallberg Matti, Bergman Tomas, Silveira Angela, Unson Cecille, Rollins-Smith Louise, Silberring Jerzy, Richardson Malcom, Kuusela Pentti and Lankinen Hilkka, Antibiotic Properties of Novel Synthetic Temporin A Analogs and a Cecropin A-Temporin A Hybrid Peptide, Protein & Peptide Letters 2002; 9 (6) . https://dx.doi.org/10.2174/0929866023408409
DOI https://dx.doi.org/10.2174/0929866023408409 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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