A Convenient Method for the Synthesis of Cprotected Esters of Boc- / Z-α,α- Dialkylamino Acids by the Mixed Carboxylic - Carbonic Anhydride Method

Title: A Convenient Method for the Synthesis of Cprotected Esters of Boc- / Z-α,α- Dialkylamino Acids by the Mixed Carboxylic - Carbonic Anhydride Method

Volume: 9 Issue: 4

Author(s): Vommina V. Suresh Babu, Kuppanna Ananda and Ganga-Ramu Vasanthakumar

Affiliation:

Keywords: Cprotected Esters, Dialkylamino Acids, Carbonic Anhydride, chloroformate

Abstract: The synthesis of C-protected esters of Boc- / Z-α,α-dialkylamino acids is accomplished by using alkyl / aryl chloroformate in presence of DMAP as a catalyst. The reaction proceeds through mixed carboxylic-carbonic anhydride, which was monitored by IR. The reaction was clean and complete in about 2 hr. All the esters prepared have been obtained in good yield and are fully characterized.

Cite this article as:

Suresh Babu V. Vommina, Ananda Kuppanna and Vasanthakumar Ganga-Ramu, A Convenient Method for the Synthesis of Cprotected Esters of Boc- / Z-α,α- Dialkylamino Acids by the Mixed Carboxylic - Carbonic Anhydride Method, Protein & Peptide Letters 2002; 9 (4) . https://dx.doi.org/10.2174/0929866023408616