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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Novel “Three-in-one” Peptide Device for Genetic Drug Delivery

Author(s): Jason Smith, Jesse Guidry and Pernilla Wittung-Stafshede

Volume 10, Issue 1, 2003

Page: [1 - 7] Pages: 7

DOI: 10.2174/0929866033408291

Price: $65

Abstract

We here describe a new strategy for the delivery of oligonucleotides to cells that is based on the use of a short peptide containing three functional units: a membrane-penetrating segment, a DNA-binding domain and a cell-localization sequence. The designed vector binds strongly to oligonucleotides and has membrane-perturbing abilities in vitro. This type of multi-functional device may be a powerful tool to achieve efficient delivery of genetic drugs in vivo.

Keywords: antisense, oligonucleotides, drug-delivery, circular dichroism, fluorescence, liposomes, carboxyfluorescein, peptide device, genetic drug delivery

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