Generic placeholder image

Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Oxidation of Goat Hepatic Galectin-1 Induces Change in Secondary Structure

Author(s): Abhay H. Pande, Rajesh K. Gupta Sumati and Krishnan Hajela

Volume 10, Issue 3, 2003

Page: [265 - 275] Pages: 11

DOI: 10.2174/0929866033478960

Price: $65


Galectin-1 requires a reducing environment for its lectin activity and the carbohydrate binding function is destroyed in oxidizing condition. In this report we provide direct evidence that the oxidation of goat hepatic galectin-1 perturbs its carbohydrate recognition domain and this could be due to changes in secondary structure of goat hepatic galectin-1. Conformational changes in goat hepatic galectin-1 due to oxidation were investigated by absorption, fluorescence and circular dichroism measurements.

Keywords: galectin-1, oxidation, conformational change

Rights & Permissions Print Export Cite as
© 2023 Bentham Science Publishers | Privacy Policy