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CNS & Neurological Disorders - Drug Targets


ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

Glycoconjugates: Roles in Neural Diseases Caused by Exogenous Pathogens

Author(s): Cara-Lynne Schengrund

Volume 5, Issue 4, 2006

Page: [381 - 389] Pages: 9

DOI: 10.2174/187152706777950701

Price: $65


Numerous reports indicate that lipid or protein associated carbohydrates are essential for infection of cells by various viruses, bacteria, or bacterial toxins, some of which affect the nervous system. Examples of such pathogens include tetanus and botulinum neurotoxin, Shiga and Shiga-like toxins, Borrelia burgdorferi, Mycobacterium leprae, and human immunodeficiency virus. This review discusses evidence indicating that carbohydrates are essential for these pathogens to induce their deleterious effects, the putative function of the carbohydrates, and how this knowledge might be used to combat the effects of the pathogen.

Keywords: Botulinum toxin, tetanus toxin, Lyme disease, leprosy, HIV, glycosphingolipids, multivalent carbohydrate ligands, carbohydrate antigens

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