Abstract
Bacterial biosynthesis of lysine has come under increased scrutiny as a target for novel antibacterial agents as it provides both lysine for protein synthesis and meso-diaminopimelate for construction of the bacterial peptidoglycan cell wall. Recent studies of the enzymes of the lysine biosynthetic pathway, development of inhibitors and investigations of their antibacterial properties are discussed.
Keywords: lysine, dap pathway, diaminopimelate, antibiotics, enzyme inhibitors
Mini-Reviews in Medicinal Chemistry
Title: Inhibitors of Lysine Biosynthesis as Antibacterial Agents
Volume: 3 Issue: 2
Author(s): Craig A. Hutton, Timothy J. Southwood and Jennifer J. Turner
Affiliation:
Keywords: lysine, dap pathway, diaminopimelate, antibiotics, enzyme inhibitors
Abstract: Bacterial biosynthesis of lysine has come under increased scrutiny as a target for novel antibacterial agents as it provides both lysine for protein synthesis and meso-diaminopimelate for construction of the bacterial peptidoglycan cell wall. Recent studies of the enzymes of the lysine biosynthetic pathway, development of inhibitors and investigations of their antibacterial properties are discussed.
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Cite this article as:
Hutton A. Craig, Southwood J. Timothy and Turner J. Jennifer, Inhibitors of Lysine Biosynthesis as Antibacterial Agents, Mini-Reviews in Medicinal Chemistry 2003; 3 (2) . https://dx.doi.org/10.2174/1389557033405359
DOI https://dx.doi.org/10.2174/1389557033405359 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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