Abstract
Vitamin D is a seco-steroid hormone with multiple functions in the nervous system. Physiological brain mechanisms of vitamin D and its receptors include neuroprotection, antiepileptic effects, immunomodulation, possible interplay with several brain neurotransmitter systems and hormones, as well as the regulation of behaviours. Here we review the important role of the vitamin D neuroendocrine system in the brain, and outline perspectives for the search for novel neurotropic drugs to treat various vitamin D-related dysfunctions.
Keywords: Vitamin D, neurosteroid hormone, brain disorders, new drugs
CNS & Neurological Disorders - Drug Targets
Title: The Vitamin D Neuroendocrine System as a Target for Novel Neurotropic Drugs
Volume: 5 Issue: 3
Author(s): A. V. Kalueff, A. Minasyan, T. Keisala, M. Kuuslahti, S. Miettinen and P. Tuohimaa
Affiliation:
Keywords: Vitamin D, neurosteroid hormone, brain disorders, new drugs
Abstract: Vitamin D is a seco-steroid hormone with multiple functions in the nervous system. Physiological brain mechanisms of vitamin D and its receptors include neuroprotection, antiepileptic effects, immunomodulation, possible interplay with several brain neurotransmitter systems and hormones, as well as the regulation of behaviours. Here we review the important role of the vitamin D neuroendocrine system in the brain, and outline perspectives for the search for novel neurotropic drugs to treat various vitamin D-related dysfunctions.
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Cite this article as:
Kalueff V. A., Minasyan A., Keisala T., Kuuslahti M., Miettinen S. and Tuohimaa P., The Vitamin D Neuroendocrine System as a Target for Novel Neurotropic Drugs, CNS & Neurological Disorders - Drug Targets 2006; 5 (3) . https://dx.doi.org/10.2174/187152706784111506
DOI https://dx.doi.org/10.2174/187152706784111506 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
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