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CNS & Neurological Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

The Vitamin D Neuroendocrine System as a Target for Novel Neurotropic Drugs

Author(s): A. V. Kalueff, A. Minasyan, T. Keisala, M. Kuuslahti, S. Miettinen and P. Tuohimaa

Volume 5 , Issue 3 , 2006

Page: [363 - 371] Pages: 9

DOI: 10.2174/187152706784111506

Price: $65

Abstract

Vitamin D is a seco-steroid hormone with multiple functions in the nervous system. Physiological brain mechanisms of vitamin D and its receptors include neuroprotection, antiepileptic effects, immunomodulation, possible interplay with several brain neurotransmitter systems and hormones, as well as the regulation of behaviours. Here we review the important role of the vitamin D neuroendocrine system in the brain, and outline perspectives for the search for novel neurotropic drugs to treat various vitamin D-related dysfunctions.

Keywords: Vitamin D, neurosteroid hormone, brain disorders, new drugs


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