Novel Anthraquinone-Carbohydrate Hybrids: The Significant Improvement of the DNA Photocleaving Activity and the Cytotoxic Selectivity

Title: Novel Anthraquinone-Carbohydrate Hybrids: The Significant Improvement of the DNA Photocleaving Activity and the Cytotoxic Selectivity

Volume: 1 Issue: 1

Author(s): Kazunobu Toshima, Yoko Nakajima, Yutaka Maeda and Shuichi Matsumura

Affiliation:

Keywords: anthraquinone, carbohydrate, photoirradiation, dna cleavage, cancer cells, cytotoxicity

Abstract: Novel anthraquinone-carbohydrate hybrids were designed and synthesized as artificial DNA photocleavers. They were found to show high DNA cleaving activity under irradiation with a long wavelength UV light without any additives and also exhibited selective cytotoxicity against HeLa S3 cancer cells with the photoirradiation.

Cite this article as:

Toshima Kazunobu, Nakajima Yoko, Maeda Yutaka and Matsumura Shuichi, Novel Anthraquinone-Carbohydrate Hybrids: The Significant Improvement of the DNA Photocleaving Activity and the Cytotoxic Selectivity, Letters in Organic Chemistry 2004; 1 (1) . https://dx.doi.org/10.2174/1570178043488581