Quaternary Heteroarenium Salts as the Competitive Inhibitors of the Brain Acetylcholinesterase

Title: Quaternary Heteroarenium Salts as the Competitive Inhibitors of the Brain Acetylcholinesterase

Volume: 1 Issue: 2

Author(s): Kamil Kuca, Jiri Cabal, Jiri Patocka and Vlastimil Dohnal

Affiliation:

Keywords: acetylcholinesterase, heteroarenium salts, inhibition, reactivation

Abstract: The interaction of seventeen heteroarenium salts with the enzyme acetylcholinesterase was investigated using in vitro experiments. Rat brains were used as a source of the enzyme. All compounds involved in this study were found to be competitive acetylcholinesterase inhibitors. 10-methyl-acridinium iodide seems to be the most potent acetylcholinesterase inhibitor.

Cite this article as:

Kuca Kamil, Cabal Jiri, Patocka Jiri and Dohnal Vlastimil, Quaternary Heteroarenium Salts as the Competitive Inhibitors of the Brain Acetylcholinesterase, Letters in Drug Design & Discovery 2004; 1 (2) . https://dx.doi.org/10.2174/1570180043485509