Differential Desensitization of Somatostatin Receptor Subtypes in AtT-20 Cells

Fredric   C.   Mazza; Allan   D.   Blake

Abstract

Nonpeptidyl agonists for the somatostatin (SRIF) receptor family have been developed. We have studied the desensitization effects for two of these agonists upon SRIF receptor function in AtT-20 cells, a neuroendocrine tumor cell, which endogenously expresses two distinct SRIF receptor, subtypes. We observe that SRIF and the nonpeptidyl, subtype selective agonists, differentially regulate SRIF receptor subtypes in the AtT-20 cell.

Keywords: Somatostatin,, nonpeptidyl agonists,, receptor subtype,, desensitization,

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