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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Differential Desensitization of Somatostatin Receptor Subtypes in AtT-20 Cells

Author(s): Fredric C. Mazza and Allan D. Blake

Volume 11, Issue 2, 2004

Page: [141 - 147] Pages: 7

DOI: 10.2174/0929866043478239

Price: $65


Nonpeptidyl agonists for the somatostatin (SRIF) receptor family have been developed. We have studied the desensitization effects for two of these agonists upon SRIF receptor function in AtT-20 cells, a neuroendocrine tumor cell, which endogenously expresses two distinct SRIF receptor, subtypes. We observe that SRIF and the nonpeptidyl, subtype selective agonists, differentially regulate SRIF receptor subtypes in the AtT-20 cell.

Keywords: Somatostatin,, nonpeptidyl agonists,, receptor subtype,, desensitization,

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