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Mini-Reviews in Organic Chemistry


ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

DNA, PNA, and Their Derivatives for Precise Genotyping of SNPs

Author(s): A. Kuzuya, J.- M. Zhou and M. Komiyama

Volume 1, Issue 1, 2004

Page: [125 - 131] Pages: 7

DOI: 10.2174/1570193043488999


Two new approaches for SNP genotyping are described. The one is based on tandem site-selective RNA scission and the genotype is determined by MALDI-TOF / MS analyses of clipped short RNA. The other is visual SNP genotyping with combinations of peptide nucleic acid (PNA) and single-stranded DNA specific nucleases.

Keywords: snp genotyping, rna, pna, selective scission, acridine, nuclease

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