Abstract
Two new approaches for SNP genotyping are described. The one is based on tandem site-selective RNA scission and the genotype is determined by MALDI-TOF / MS analyses of clipped short RNA. The other is visual SNP genotyping with combinations of peptide nucleic acid (PNA) and single-stranded DNA specific nucleases.
Keywords: snp genotyping, rna, pna, selective scission, acridine, nuclease
Mini-Reviews in Organic Chemistry
Title: DNA, PNA, and Their Derivatives for Precise Genotyping of SNPs
Volume: 1 Issue: 1
Author(s): A. Kuzuya, J.- M. Zhou and M. Komiyama
Affiliation:
Keywords: snp genotyping, rna, pna, selective scission, acridine, nuclease
Abstract: Two new approaches for SNP genotyping are described. The one is based on tandem site-selective RNA scission and the genotype is determined by MALDI-TOF / MS analyses of clipped short RNA. The other is visual SNP genotyping with combinations of peptide nucleic acid (PNA) and single-stranded DNA specific nucleases.
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Cite this article as:
Kuzuya A., Zhou M. J.- and Komiyama M., DNA, PNA, and Their Derivatives for Precise Genotyping of SNPs, Mini-Reviews in Organic Chemistry 2004; 1 (1) . https://dx.doi.org/10.2174/1570193043488999
DOI https://dx.doi.org/10.2174/1570193043488999 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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