Abstract
The naturally-occurring alkaloid ibogaine, found in the West African shrub Tabernanthe iboga, possesses the ability to diminish self-administration of substances of abuse, such as cocaine, heroin and alcohol. This was the lead structure for the design of a 16-member library of N-substituted isoquinuclidines. A solution-phase method for their synthesis is described.
Keywords: Ibogaine, isoquinuclidines, 2-azabicyclo[2.2.2]octanes, parallel synthesis, drug dependence
Letters in Drug Design & Discovery
Title: Solution-Phase Parallel Synthesis of N-Substituted Isoquinuclidines
Volume: 1 Issue: 4
Author(s): M. S. Levi, M. O.F. Khan and R. F. Borne
Affiliation:
Keywords: Ibogaine, isoquinuclidines, 2-azabicyclo[2.2.2]octanes, parallel synthesis, drug dependence
Abstract: The naturally-occurring alkaloid ibogaine, found in the West African shrub Tabernanthe iboga, possesses the ability to diminish self-administration of substances of abuse, such as cocaine, heroin and alcohol. This was the lead structure for the design of a 16-member library of N-substituted isoquinuclidines. A solution-phase method for their synthesis is described.
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Cite this article as:
Levi S. M., Khan O.F. M. and Borne F. R., Solution-Phase Parallel Synthesis of N-Substituted Isoquinuclidines, Letters in Drug Design & Discovery 2004; 1 (4) . https://dx.doi.org/10.2174/1570180043398597
DOI https://dx.doi.org/10.2174/1570180043398597 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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