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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Solution-Phase Parallel Synthesis of N-Substituted Isoquinuclidines

Author(s): M. S. Levi, M. O.F. Khan and R. F. Borne

Volume 1 , Issue 4 , 2004

Page: [384 - 386] Pages: 3

DOI: 10.2174/1570180043398597

Price: $65

Abstract

The naturally-occurring alkaloid ibogaine, found in the West African shrub Tabernanthe iboga, possesses the ability to diminish self-administration of substances of abuse, such as cocaine, heroin and alcohol. This was the lead structure for the design of a 16-member library of N-substituted isoquinuclidines. A solution-phase method for their synthesis is described.

Keywords: Ibogaine, isoquinuclidines, 2-azabicyclo[2.2.2]octanes, parallel synthesis, drug dependence


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