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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Design and Cytotoxicity Analysis of a Conjugate Containing the New DGalactose- Binding Lectin SELld and the Non-Toxic Type 2 Ribosome- Inactivating Protein Nigrin b

Author(s): Jorge Benitez, M. Angeles Rojo, Raquel Munoz, J. Miguel Ferreras, Pilar Jimenez and Tomas Girbes

Volume 1 , Issue 4 , 2004

Page: [361 - 367] Pages: 7

DOI: 10.2174/1570180043398687

Price: $65


Conjugates containing nigrin b (two-chain RIP) linked to a new lectin (SELld) from Sambucus ebulus L. have been designed. They retain the anti-ribosomal inhibitory activity of nigrin b but, in contrast to nigrin b, they exerted strong cytotoxicity on COLO 320 and HeLa cells, which ran in parallel with DNA fragmentation.

Keywords: nigrin b, selld, ribosome-inactivating proteins, colo 320 cells, cancer therapy, apoptosis

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