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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Novel Therapeutic Approaches to Mitochondrial Disease

Author(s): J. A. Ibdah and R. M. Payne

Volume 1 , Issue 4 , 2004

Page: [308 - 313] Pages: 6

DOI: 10.2174/1570180043398506

Price: $65

Abstract

Defects in mitochondrial function cause serious pediatric morbidity and mortality. Most mitochondrial disorders are caused by nuclear gene defects. To overcome the limitations of viral vectors for delivering gene products to mitochondria, we used protein transfection domains that cross cell membranes to deliver proteins expressed by nuclear genes to mitochondria.

Keywords: fatty acids, oxidation, ptd, tat, fusion proteins, mitochondria


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