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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Cyclosporin A: A Therapeutic Strategy in Allergic Diseases

Author(s): Nettis Eustachio, Colanardi Maria Cristina and Ferrannini Antonio

Volume 1 , Issue 4 , 2004

Page: [300 - 307] Pages: 8

DOI: 10.2174/1570180043398650

Price: $65


Cyclosporin A (CsA) is a fungal metabolite that has immunomodulatory and anti-inflammatory effects. Cyclosporin binds to cyclophilin, inhibiting CD4-T-cell activation. In this paper we discuss the mechanism of action of CsA and its role as a novel approach for the treatment of allergic disease.

Keywords: allergic contact dermatitis, asthma, atopic dermatitis, cyclosporin, ocular allergic diseases, urticaria

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