Abstract
In mammals the M1 aminopeptidase family consists of nine different proteins, five of which are integral membrane proteins. The aminopeptidases are defined by two motifs in the catalytic domain; a zinc binding motif HEXXH-(X18)-E and an exopeptidase motif GXMEN. Aminopeptidases of this family are able to cleave a broad range of peptides down to only to a single peptide. This ability to either generate or degrade active peptide hormones is the focus of this review. In addition to their capacity to degrade a range of peptides a number of these aminopeptidases have novel functions that impact on cell signalling and will be discussed.
Keywords: aminopeptidase, apa, apn, trh-de, eraap, angiotensin iv, irap
Protein & Peptide Letters
Title: Membrane Bound Members of the M1 Family: More Than Aminopeptidases
Volume: 11 Issue: 5
Author(s): Anthony L. Albiston, Siying Ye and Siew Yeen Chai
Affiliation:
Keywords: aminopeptidase, apa, apn, trh-de, eraap, angiotensin iv, irap
Abstract: In mammals the M1 aminopeptidase family consists of nine different proteins, five of which are integral membrane proteins. The aminopeptidases are defined by two motifs in the catalytic domain; a zinc binding motif HEXXH-(X18)-E and an exopeptidase motif GXMEN. Aminopeptidases of this family are able to cleave a broad range of peptides down to only to a single peptide. This ability to either generate or degrade active peptide hormones is the focus of this review. In addition to their capacity to degrade a range of peptides a number of these aminopeptidases have novel functions that impact on cell signalling and will be discussed.
Export Options
About this article
Cite this article as:
Albiston L. Anthony, Ye Siying and Chai Yeen Siew, Membrane Bound Members of the M1 Family: More Than Aminopeptidases, Protein & Peptide Letters 2004; 11 (5) . https://dx.doi.org/10.2174/0929866043406643
DOI https://dx.doi.org/10.2174/0929866043406643 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Testosterone Replacement Therapy in Older Male Subjective Memory Complainers: Double-Blind Randomized Crossover Placebo-Controlled Clinical Trial of Physiological Assessment and Safety
CNS & Neurological Disorders - Drug Targets Medico-Legal Evaluation of Fatal Perinatal Asphyxia
Current Pediatric Reviews VEGF Inhibitors in Cancer Therapy
Current Pharmaceutical Design Coronary Microvascular and Cardiac Dysfunction Due to Homocysteine Pathometabolism; A Complex Therapeutic Design
Current Pharmaceutical Design Subject Index to Volume 2
Current Pharmacogenomics The Role of Coagulation and Fibrinolysis in the Pathogenesis of Acute Lung Injury
Current Respiratory Medicine Reviews Editorial [Hot topic: Adenosine Receptor Ligands: Where Are We, and Where Are We Going? (Guest Editors: Tiziano Tuccinardi and Adriano Martinelli)]
Current Topics in Medicinal Chemistry Editorial (Thematic Issue: Enantioselective Synthesis in Organic and Medicinal Chemistry)
Current Topics in Medicinal Chemistry Biopeptides in Milk: Opiate and Antithrombotic Effects
Mini-Reviews in Medicinal Chemistry Garlic-Derived Allyl Sulfides in Cancer Therapy
Anti-Cancer Agents in Medicinal Chemistry Potential Linkage Between Cerebrovascular Diseases and Metabolic Syndrome
Current Drug Metabolism Electrotransfer into Skeletal Muscle for Protein Expression
Current Gene Therapy Conditional Cardiac Overexpression of S100A6 Attenuates Myocyte Hypertrophy and Apoptosis Following Myocardial Infarction
Current Pharmaceutical Design Preparing for Pregnancy: A Body Weight Perspective and Update of the Literature
Current Nutrition & Food Science Subject Index To Volume 13
Current Medicinal Chemistry Flavonoids in Atherosclerosis: An Overview of Their Mechanisms of Action
Current Medicinal Chemistry Metabolic Syndrome and Non-Cardiac Vascular Diseases: An Update from Human Studies
Current Pharmaceutical Design Jak2 and Reactive Oxygen Species: A Complex Relationship
Current Chemical Biology Respiratory Gas Exchange During Exercise in Children with Congenital Heart Disease: Methodology and Clinical Concepts
Current Respiratory Medicine Reviews Hemodynamic Regulation of Metallopeptidases within the Vasculature
Protein & Peptide Letters