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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Neprilysin 2: A Novel Messenger Peptide-Inactivating Metalloprotease

Author(s): Tanja Ouimet

Volume 11 , Issue 5 , 2004

Page: [479 - 489] Pages: 11

DOI: 10.2174/0929866043406625

Price: $65

Abstract

Neprilysin 2 is a recently identified glycoprotein displaying the highest degree of sequence identity with neprilysin (EC 3.4.24.11), the prototypical member of the M13 family of zinc-dependent metalloproteases. Whereas neprilysin has been shown to be involved in the inactivation of endogenous messenger peptides, like enkephalins and tachykinins, the true physiological functions of neprilysin 2 remain unknown.

Keywords: neprilysin, neprilysin 2, m13 family of metalloproteases, peptide inactivation, enkephalin, substance p, thiorphan, phosphoramidon


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