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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

The Role of Neuropeptide Processing Enzymes in Endocrine (Prostate) Cancer: EC 3.4.24.15 (EP24.15)

Author(s): Todd A. Swanson, Sandra I. Kim, Michael Myers, Amanda Pabon, Keith D. Philibert, Mina Wang and Marc J. Glucksman

Volume 11 , Issue 5 , 2004

Page: [471 - 478] Pages: 8

DOI: 10.2174/0929866043406607

Price: $65

Abstract

The zinc metalloendopeptidase EC3.4.24.15 [EP24.15, thimet oligopeptidase], a neuropeptide processing enzyme, is central to the formation and degradation of many bioactive peptides in the neural proteome, and is highly expressed in normal prostate. EP24.15 actions are increased in androgen-dependent prostate cancer compared to androgen-independent; augmented by androgen treatment, and inhibited by clinical GnRH analogs. The “neural” prostate includes: neuropeptides, cognate receptors and processing enzymes regulating signaling of peptide-mediated neural inputs.

Keywords: prostate, cancer, endocrine, proteome, neuropeptide, metallopeptidase, metalloenzyme


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