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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Secretase-Mediated Cell Surface Shedding of the Angiotensin-Converting Enzyme

Author(s): Edward T. Parkin, Anthony J. Turner and Nigel M. Hooper

Volume 11 , Issue 5 , 2004

Page: [423 - 432] Pages: 10

DOI: 10.2174/0929866043406544

Price: $65


Angiotensin-converting enzyme (ACE) is an example of a membrane-bound protein, which is shed from the cell surface in a soluble form by a post-translational proteolytic cleavage event involving a secretase. The secretase cleavage site in somatic ACE has been mapped to Arg-1203 / Ser-1204, 24 residues proximal to the membrane-anchoring domain and the ADAM (‘a d isintegrin a nd m etalloprotease’) family of proteins may be involved in ACE shedding.

Keywords: ace, angiotensin, disintegrin, hypertension, metalloproteinase, proteolysis, secretase, shedding

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