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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Kinase Chemogenomics: Targeting the Human Kinome for Target Validation and Drug Discovery

Author(s): E. ter Haar, W. P. Walters, S. Pazhanisamy, P. Taslimi, A. C. Pierce, G. W. Bemis, F. G. Salituro and S. L. Harbeson

Volume 4, Issue 3, 2004

Page: [235 - 253] Pages: 19

DOI: 10.2174/1389557043487367

Price: $65


Chemogenomics is a gene family-based approach to drug discovery and target validation. This review will summarize the application of this interdisciplinary approach to the protein kinases of the human genome with emphasis upon the synergies and efficiencies to be gained. Specific examples from the SAPKfamily will be discussed.

Keywords: chemogenomics, kinases, structure-based drug design

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