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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

New Drug Design for Gene Therapy - Taking Advantage of Introns

Author(s): Shi-Lung Lin and Shao-Yao Ying

Volume 1 , Issue 3 , 2004

Page: [256 - 262] Pages: 7

DOI: 10.2174/1570180043398939

Price: $65

Abstract

A novel gene modulation system was identified within mammalian introns, regulating intracellular gene transcripts homologous to certain 5-proximal non-snRNP-binding regions of spliced introns. This gene modulation system can be manipulated for the analysis of gene function and development of gene-specific therapeutics, using artificial introns with 5-proximal hairpin inserts.

Keywords: artificial intron, posttranscriptional gene silencing, pol-II-directed rna interference (rnai), d-rnai, mirna generation, rna splicing, intron-mediated enhancement (ime)


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