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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

In-Vitro Searching for a New Potent Reactivator of Acetylcholinesterase Inhibited by Nerve Agent VX

Author(s): K. Kuca, J. Cabal, J. Bajgar and D. Jun

Volume 2, Issue 1, 2005

Page: [23 - 25] Pages: 3

DOI: 10.2174/1570180053398398

Price: $65

Abstract

Organophosphorus compounds, especially nerve agents, inhibit enzyme acetylcholinesterase (AChE; EC 3.1.1.7) in an irreversible manner. Atropine plus an oxime reactivator are used as an effective treatment of organophosphate poisoning. In this work, we have evaluated reactivation potency of twenty reactivators of different chemical structures in reactivation of VX-inhibited AChE. Rat brain AChE homogenate was used as the appropriate source of the enzyme. According to our results, trimedoxime seems to be the most potent reactivator of VX-inhibited AChE at the concentration 10-3 M.

Keywords: nerve agent, reactivation, inhibition, acetylcholinesterase, trimedoxime, oxime, vx agent


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