Abstract
The series of quinaldine derivatives were prepared, some of them by means of novel synthetic methods. The synthetic approach, analytical and spectroscopic data of all newly synthesized compounds are presented. The prepared compounds were tested for their in vitro antifungal activity as well as for their photosynthesis-inhibiting activity (the inhibition of photosynthetic electron transport in spinach chloroplasts (Spinacia oleracea L.) and the reduction of chlorophyll content in Chlorella vulgaris Beij.). Structure-activity relationships among the chemical structure, the physical properties and the biological activities of the evaluated compounds are discussed in the article.
Keywords: quinaldine derivatives, in vitro antifungal activity, photosynthesis inhibition, lipophilicity, structure-activity relationships, chlorella vulgaris, spinach chloroplasts
Medicinal Chemistry
Title: Quinaldine Derivatives: Preparation and Biological Activity
Volume: 1 Issue: 6
Author(s): J. Jampilek, M. Dolezal, J. Kunes, V. Buchta, L. Silva and K. Kralova
Affiliation:
Keywords: quinaldine derivatives, in vitro antifungal activity, photosynthesis inhibition, lipophilicity, structure-activity relationships, chlorella vulgaris, spinach chloroplasts
Abstract: The series of quinaldine derivatives were prepared, some of them by means of novel synthetic methods. The synthetic approach, analytical and spectroscopic data of all newly synthesized compounds are presented. The prepared compounds were tested for their in vitro antifungal activity as well as for their photosynthesis-inhibiting activity (the inhibition of photosynthetic electron transport in spinach chloroplasts (Spinacia oleracea L.) and the reduction of chlorophyll content in Chlorella vulgaris Beij.). Structure-activity relationships among the chemical structure, the physical properties and the biological activities of the evaluated compounds are discussed in the article.
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Cite this article as:
Jampilek J., Dolezal M., Kunes J., Buchta V., Silva L. and Kralova K., Quinaldine Derivatives: Preparation and Biological Activity, Medicinal Chemistry 2005; 1 (6) . https://dx.doi.org/10.2174/157340605774598108
DOI https://dx.doi.org/10.2174/157340605774598108 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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