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Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

Competitive Reactions of L-Methionine and 5-GMP Towards Platinum (II) Complexes

Author(s): T. Soldatovic, P. Canovic, D. Canovic and Z. D. Bugarcic

Volume 1 , Issue 6 , 2005

Page: [547 - 561] Pages: 15

DOI: 10.2174/157340605774598117

Price: $65

Abstract

The complex-formation reactions of the platinum(II) complexes, [Pt(dien)H2O]2+, [PtCl(dien)]+ and [PtBr(dien)]+ (dien is diethylenetriamine) with some biologically relevant ligands such as inosine (INO), inosine-5- monophosphate (5-IMP), guanosine-5-monophosphate (5-GMP), glutathione (GSH) and L-methionine (S-meth), were studied by UV-Vis (UV-Visible) spectrophotometry and 1H NMR spectroscopy. Reactions of the [PtCl(dien)]+ with Lmethionine were studied in the presence and absence of 5-GMP. The rate constants clearly showed a kinetic preference toward L-methionine. However, competitive reactions of [PtCl(dien)]+ with L-methionine and 5-GMP demonstrated initially rapid formation of [Pt(dien)(S-meth)]2+ followed by displacement of L-methionine by 5-GMP. In the later stages the concentration of [Pt(dien)(N7-GMP )]2+ is predominant. The results are analyzed in reference to the anti-tumour activity of Pt(II) complexes.

Keywords: platinum(II), l-methionine, 5'-gmp, antitumor agents


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